Time is her tissue image

CroFab®: The only FDA-approved product derived exclusively from US snakes and approved to treat all North American pit viper envenomations in adult and pediatric patients.1,2

Proven to control local, systemic, and hematologic effects of envenomation1,3*

Established performance backed by over 15 years of clinical experience2

Over 50,000 patients treated to date2

INITIAL CONTROL FOR SNAKE ENVENOMATION INVOLVES
HALTING LOCAL, SYSTEMIC, AND HEMATOLOGIC EFFECTS1

Select an image to explore the effects.

Local effects

SYMPTOMS4

  • Swelling, tenderness, and pain
  • Redness
  • Ecchymosis
  • Bullae or blebs
  • Soft-tissue necrosis

CONSEQUENCES4-7

  • Partial or complete loss of affected limbs
  • Loss of joint functionality
  • Loss or impairment of tactile sensation
  • Infection
  • Cosmetic issues

Systemic effects

SYMPTOMS4

  • Hypotension
  • Bleeding beyond the puncture site
  • Refractory vomiting
  • Diarrhea
  • Angioedema
  • Neurotoxicity

CONSEQUENCES4,8

  • Death is a possibility
  • Irreversible damage
  • Respiratory compromise/failure
  • Neurologic deficits
  • Cardiovascular/pulmonary collapse due to shock
  • End organ damage

Hematologic effects

SYMPTOMS4

  • Decreased fibrinogen
  • Elevated prothrombin time or international normalized ratio
  • Thrombocytopenia

CONSEQUENCES4,8

  • Coagulation abnormalities
  • Increased risk of bleeding complications (0.5%)
  • Significant ecchymosis
  • Anemia

Crofab® Patient Testimonials

PREPARE TO STRIKE BACK AGAINST PIT VIPER ENVENOMATION

Triple Control

Gain triple control with CroFab®*

CroFab® is proven to halt local effects, resolve systemic effects, and reduce coagulation abnormalities.1,3

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Treatment Algorithm

How to treat a snakebite

Use the interactive guide with step-by-step instructions on how to treat a snakebite.

TREAT NOW > LEARN MORE >
Dosing and Administration

Dosing and administration

Dose CroFab® appropriately to gain and continue control of envenomation.1,4

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How to Order CroFab®

Expert consensus guidelines for stocking of antidotes in
hospitals that provide emergency care9

All hospitals that provide emergency care should stock 12 to 18 vials of CroFab®—enough antidote to treat
one patient for 8 to 24 hours

*Efficacy determined using the snakebite severity score (SSS), a validated objective tool for the clinical evaluation of North American pit viper snakebite in adults. The total score reflects patient evaluation on 6 dimensions: cardiovascular system, local wound, gastrointestinal system, hematologic symptoms, pulmonary system, and central nervous system. The higher the total score, the more severe the snakebite.1


References:

1. CroFab® [prescribing Information]. BTG International Inc; January 2018. 2. Data on file. Conshohocken, PA; BTG International Inc. 2019. 3. Dart RC, Seifert SA, Boyer LV, et al. A randomized multicenter trial of crotalinae polyvalent immune Fab (ovine) antivenom for the treatment for crotaline snakebite in the United States. Arch Intern Med. 2001;161(16):2030-2036. 4. Lavonas EJ, Ruha AM, Banner W, et al. Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop. BMC Emerg Med. 2011;11:2. 5. Nelson L, Lewin N, Howland M, et al. Goldfrank’s Toxicologic Emergencies. 9th ed. McGraw Hill Medical; 2010:1601-1609. 6. Ruha AM, Kleinschmidt KC, Greene S, et al. The epidemiology, clinical course, and management of snakebites in the North American Snakebite Registry. J Med Toxicol. 2017;13(4):309-320. 7. Mackessy SP, ed. Handbook of Venoms and Toxins of Reptiles. Boca Raton, FL: CRC Press; 2010. 8. Gold BS, Dard RC, Barish RA. Bites of venomous snakes. N Engl J Med. 2002;347(5):347-356. 9. Dart RC, Goldfrank LR, Erstad BL, et al. Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care. Ann Emerg Med. 2018;71(3):314-325.