What is CroFab®

Approved in 2000, CroFab® was designed to reduce the high incidence of hypersensitivity that occurred with previous antivenom therapy, and to provide a geographically relevant antivenom. In the years since, CroFab® has become the antivenom that healthcare professionals rely on for the treatment of North American pit viper envenomation.1,2

Mechanism of Action

CroFab® consists of venom-specific Fab fragments of immunoglobulin G (IgG) that work by binding to and neutralizing venom toxins, facilitating their redistribution away from target tissues and their elimination from the body.1

CroFab® mechanism of action

For illustrative purposes only.


How CroFab® Works

  • Venom-specific Fab binds and neutralizes venom toxins1
  • Facilitates venom toxin redistribution away from target tissues1
  • Facilitates venom toxin elimination from the body1

Understand how CroFab® is clinically proven to help halt envenomation.


1. CroFab® [prescribing Information]. BTG International Inc; May 2017. 2. Lavonas EJ, Ruha AM, Banner W, et al. Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop. BMC Emerg Med. 2011;11:2.