Production

CroFab® Production: Purity, Precision, Purpose

Comprehensive coverage of all US pit viper venoms regardless of severity11

  • Produced from US snakes to fight US snake venom
  • Proven cross-reactivity with 10 common North American snake venoms
    • Includes rattlesnakes (Mojave type A venom, western and eastern diamondbacks), cottonmouths/water moccasins, and copperheads1

Collection: Pure venom validated by testing11

  • Controlled collection, testing, and certification of venom from US snakes in their habitat
 

Immunization: Highest level of biosecurity for host animals11

  • Australian sheep: the cleanest host animal
    • Free of prions and viruses
  • Venom from individual species incubated in separate sheep herds
    • 4 separate high-potency, monospecific antivenoms combined to create CroFab®
  • Sheep IgG is less immunogenic than equine or porcine IgG

Production: Robust regulatory oversight11

  • Bioprocessing and production of antivenom with the highest level of inspection

Unique Manufacturing for Unparalleled Quality

 

A smaller molecule for faster efficacy and better safety11

 
  • Less risk of hypersensitivity
    • CroFab removes the Fc fragment
    • No risk of cross-linking antigens or formation of immune complexes
    • Faster clearance for less immune system recognition
  • Smaller molecule for more rapid, larger volume of distribution in the body
 


Affinity purification: a purer product for improved confidence11

 
  • Purification for venom-specific antibodies only—just 15% of the original material provides
    • Greater specificity
    • Fewer nonspecific foreign proteins that can cause adverse reactions
TO REPORT AN ADVERSE EVENT OR FOR 24-HOUR MEDICAL INFORMATION, CALL 1-844-293-0007.