Clinical Articles About Snakebite Managment


Publications to help you understand treatment considerations and the efficacy of leading emergency snakebite treatments

"The Efficacy of Crotalidae Polyvalent Immune Fab (Ovine) Antivenom Versus Placebo Plus Optional Rescue Therapy on Recovery From Copperhead Snake Envenomation: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial"

Annals of Emergency Medicine

Clinical trial demonstrating how treatment with FabAV can reduce limb disability.

"Unified Treatment Algorithm for the Management of Crotaline Snakebite in the United States: Results of an Evidence-Informed Consensus Workshop"

BMC Emergency Medicine

Nine experts produce and align on a unified treatment algorithm for treatment of crotaline envenomation.

"Incidence of Immediate Hypersensitivity Reaction and Serum Sickness Following Administration of Crotalidae Polyvalent Immune Fab Antivenom: A Meta-analysis"

Academic Emergency Medicine

Systematic literature review and meta-analysis of immediate hypersensitivity reactions and serum sickness from FabAV.

"Medically Significant Late Bleeding After Treated Crotaline Envenomation: A Systematic Review"

Annals of Emergency Medicine

Study to estimate the proportion of patients with crotaline snake envenomation, treated with Crotalidae polyvalent immune Fab (ovine) antivenom, who develop medically significant late bleeding.

"Affinity-Purified, Mixed Monospecific Crotalid Antivenom Ovine Fab for the Treatment of Crotalid Venom Poisoning"

Annals of Emergency Medicine

First premarketing clinical study of CroFab®, Tab001, to test the efficacy and safety of a new antivenom, affinity-purified, mixed monospecific crotalid antivenom ovine Fab, in human subjects with minimal or moderate crotalid envenomation.

"A Randomized Multicenter trial of Crotalinae Polyvalent Immune Fab (ovine) Antivenom for the Treatment for Crotaline Snakebite in the United States"

Archives of Internal Medicine

The second clinical trial of CroFab®, Tab002, and the first randomized clinical trial of antivenom in the US showing efficacy and safety of CroFab® in crotaline envenomation.

"Surgical Considerations in the Management of Pit Viper Snake Envenomation"

Journal of American College of Surgeons

A 4-member panel of experts provides recommendations based on systematic review of key clinical questions regarding the surgical management of pit viper envenomation.

"Bedside Management Considerations in the Treatment of Pit Viper Envenomation"

Journal of Emergency Nursing

Review article highlighting the possible effects of snakebites as well as their assessment and treatment.

"Incidence of allergic reactions to Crotalidae polyvalent immune Fab"

Clinical Toxicology

Retrospective study of 1,340 CroFab patients finds low incidence (1.4%) of acute hypersensitivity reactions.

Did You Know?

Treating snakebites and pit viper envenomation is about more than just knowing how to administer treatment. Make sure you’re aware of the risk, and know what to do at every step of snakebite management.

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