Review the following resources for information about pit viper envenomation, its treatment, and CroFab®.
This guide provides procedure, diagnosis, and billing codes for CroFab®, as well as contact information for reimbursement questions and support.
This fact sheet can provide your patients with everything they need to know about envenomation, venom effects, and when they will be able to leave the hospital.
This brochure guides you through reconstitution of CroFab® Crotalidae Polyvalent Immune Fab (Ovine).
Review actual case studies detailing a variety of envenomation treatment scenarios and outcomes.
The American Association of Poison Control Centers
The American Association of Poison Control Centers works to support the nation's 55 poison control centers in the work they do:
Watch this video for instructions on how to reconstitute CroFab®.
Use the interactive guide with step-by-step instructions on how to treat a snakebite.
Be prepared at every stage of envenomation management with guidance from the algorithm poster.
View webinars where experts discuss the best ways to be prepared and act quickly and effectively in the event of a snakebite.
Read clinical articles about antivenom efficacy and snakebite management.
Sign up to receive emails with emerging updates on snakebite management, new articles, and upcoming webinars.
Access resources that are critical for treating pit viper envenomation.
Review the expert consensus for managing pit viper snakebites.
View presentations by snakebite experts on envenomation and treatment.
Learn how to dose CroFab® to gain and continue control of pit viper envenomation.
Do not administer CroFab® to patients with a known history of hypersensitivity to any of its components, or to papaya or papain unless the benefits outweigh the risks and appropriate management for anaphylactic reactions is readily available.
Coagulopathy: In clinical trials, recurrent coagulopathy (the return of a coagulation abnormality after it has been successfully treated with antivenin), characterized by decreased fibrinogen, decreased platelets, and elevated prothrombin time,
occurred in approximately half of the patients studied; one patient required re-hospitalization and additional antivenin administration. Recurrent coagulopathy may persist for 1 to 2 weeks or more. Patients who experience coagulopathy due to
snakebite should be monitored for recurrent coagulopathy for up to 1 week or longer. During this period, the physician should carefully assess the need for re-treatment with CroFab® and use of any type of anticoagulant or anti-platelet drug.
Hypersensitivity Reactions: Severe hypersensitivity reactions may occur with CroFab®. In case of acute hypersensitivity reactions, including anaphylaxis and anaphylactoid reactions, discontinue infusion and institute appropriate emergency treatment.
Patients allergic to papain, chymopapain, other papaya extracts, or the pineapple enzyme bromelain may also have an allergic reaction to CroFab®. Follow-up all patients for signs and symptoms of delayed allergic reactions or serum sickness (e.g.,
rash, fever, myalgia, arthralgia).
The most common adverse reactions (incidence ≥ 5% of subjects) reported in the clinical studies were urticaria, rash, nausea, pruritus and back pain. Adverse reactions involving the skin and appendages (primarily rash, urticaria, and pruritus)
were reported in 12 of the 42 patients. Two patients had a severe allergic reaction (severe hives and a severe rash and pruritus) following treatment and one patient discontinued CroFab® due to an allergic reaction. Recurrent coagulopathy due
to envenomation and requiring additional treatment may occur.
Please see full Prescribing Information.
CroFab® Crotalidae Polyvalent Immune Fab (Ovine) is a sheep-derived antivenin indicated for the management of adult and pediatric patients with North American crotalid envenomation. The term crotalid is used to describe the Crotalinae subfamily
(formerly known as Crotalidae) of venomous snakes which includes rattlesnakes, copperheads and cottonmouths/water moccasins.
To report suspected adverse reactions, contact BTG at 1-877-377-3784 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.